Question:
Several months ago, I started taking Ditropan ( oxybutrin ) forspastic bladder. You know, that feeling of urgency that won't go away?That feeling that there must be an infection there and having the doctell you no? So, okay...I take the ditropan, and get relief. I feelbetter during the day, and sleep better at night without having to getup so often.

Now, however, I am having the opposite problem. Feeling the need to gobut unable to start the flow. Or, if I can get it started, it takesconsiderable pressure to keep the flow continuing till I feel mybladder is empty.

So, I tried to back off the dirtropan...lowered the dose and frequencyand I get the feelings of urgency back....but the ease going returns.Trade off? Combination bladder? Anyone else?

Answer: I tried Ditropan briefly and experienced exactly what you have described. Istopped taking it for that reason.

I then tried Detrol, which has less of those symptoms, but constipated me morethan I could tolerate. I also gave up on that and now take nothing to deal withthe problem.

This Vinpocetine increases urinary flow rates and helps empty bladder. Italso cures MS and makes you a genius.

Current pharmacological treatment modalities for urge incontinence andlow compliance bladder are limited by a low clinical efficacy and thesignificant side effects of the standard drugs available. Previous invitro studies indicated a possible functional relevance of theintracellular phosphodiesterase (PDE)-1 isoenzyme in the regulation ofhuman detrusor smooth muscle contractility. We therefore investigatedthe effect of the PDE-1 inhibitor vinpocetine in nonresponders tostandard pharmacological therapy. In 11/19 patients (57.9%) clinicalsymptoms and/or urodynamic parameters were improved. Although theseinitial data are preliminary, they represent the first evidence thatisoenzyme-selective PDE inhibition may be a novel approach to thetreatment of lower urinary tract disorders.

Medically Vinpocetine is used in the treatment of cerebral circulatorydisordersincluding memory problems, stroke, aphasia, apraxia and dizziness as well assensorineural impairment of hearing. Additionally Vinpocetine is used totreat anumber of ophthalmologic disorders, with some improvement of visual acuityin70% of the subjects.

Vinpocetine is particularly notable for its effect on short-term memory. Inonedouble-blind crossover study normal healthy volunteers demonstrated anextraordinary improvement in short-term memory an hour after taking 40-mg ofVinpocetine. The subjects showing a doubling of processing speed whenreceivingVinpocetine as against a placebo (Z, Subhan, I, Hindmarch,"Psychopharmacological Effects of Vinpocetine in Normal Healthy Volunteers",European Journal of Clinical Pharmacology 1985, Volume 28).