Question:
If the Prusiner model had been a true model (when did he first propoundhis model? 1985?) an invitro replication should have been successfulback in 1985. Because no invitro replication has occurred means that thedisease is really caused by a manufacturing site gone awry invivo.

Question: I would think that these protein diseases of Alzheimers andprion and Parkinson should exist in insects. Not just large animalssuch as cow, sheep and humans but also in insects. Something that canbe studied faster than animals which we have to wait for years ofdisease progression. I don't think researchers have looked into insectbrains for these protein diseases and I have a hunch that some insectsare afflicted with them. Or, some insects can be made to have the disease.If we can get insects to have these diseases, our learning curve will begreater and faster.

Can anyone help????

Answer: yes.

Huntington has been transferred to Drosophila, and good work donethere. This is the easy case, because a mutant gene is responsible forthe altered protein, so they just transferred it.

Not sure about the others.

As to natural diseases in the insects, the big question at the startis recognizing them. What would Alz in a fly look like? Remember thatthe first clue of Alz is usually complaints from the spouse.

Whether prion diseases exist in flies would first require that asuitable protein be there, one that can assume the prion behavior. Notsure how much anyone has looked yet. With the Drosophila genome done,certainly worth looking.